National Survey Investigating Hallucinogenic Trends

National Survey Investigating Hallucinogenic Trends (NSIHT): The depth to understand psychedelic use. The rigor to understand its population impact.

The National Survey Investigating Hallucinogenic Trends (NSIHT) combines in-depth measurement of real-world psychedelic experiences with rigorous population methods to understand who uses psychedelics, how they are used, their outcomes, and how use is changing across the United States.

 

Explore Our Data and Publications 

 

What makes NSIHT different?

Deep measurement

Detailed psychedelic, substance-specific measurement of behaviors, motivations, settings, experiences, benefits, risks, and outcomes.

Population-level evidence

Strategic enrichment (increased sample) of people using psychedelics combined with validated data-fusion and transport-weighting methods to generate nationally representative estimates.

Ongoing surveillance

Twice-yearly data collection designed to detect changes in psychedelic use, emerging behaviors, markets, and policies.

Explore our data and view our most recent reports here: NSIHT Data and Reports.

 

 

Designed to understand the whole picture of psychedelic use

We designed a custom surveillance system for psychedelics from the ground up with a focus on understanding people, measuring behaviors and outcomes, and studying the evolving environment.

NSIHT is intentionally designed as a flexible surveillance system capable of responding to policy changes, new products, terminology, and emerging behaviors.

 

 

Built for rigorous population science

  • 10,000+ adults reporting recent psychedelic use surveyed annually since 2024
  • 17 psychedelic, hallucinogenic, or dissociative substances captured - measured individually, including pharmaceutical and nonmedical forms
  • 2× per year repeated nation-wide data collection
  • 50 states and Washington, DC with substance-specific state estimations
  • Strong test-retest reliability of past year use of psychedelics across all 17 psychedelic substances
  • Externally validated transport-weighting methodology benchmarked against federal population surveys

 

 

How NSIHT works

NSIHT uses a sampling enrichment method to enhance data collection on adults who have used a psychedelic substance in the last 12 months.

Because psychedelic use is uncommon in the general population, NSIHT recruits enough people with recent experiences to study those behaviors in detail, then uses validated statistical methods to support population-level inference.

We accomplish this by taking the psychedelic-enriched sample and applying an externally validated transport-weighting and data-fusion approach to combine that data with a large general-population survey.

See our full methodology description here: NSIHT Data and Reports.

 

 

Who Uses Our Data

Researchers • Government Agencies • Clinicians • Policymakers • Drug Developers

 

 

Work With Us

We offer technical reports, limited datasets, and expert consultation. We also allow for sponsored content, where external researchers can answer their own questions through our tool.

Data subscriptions for regulatory or surveillance purposes are also available.

Reach out to info@rmpds.org for more information.

 

 

Funding

Data collection and investigators are supported by the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH) under Award No. R01DA064612.

Data reports and topical expertise are conducted in collaboration with the Substance Abuse and Mental Health Services Administration (SAMHSA), as well as previous methodological development validation under annual grants #75S20124P00003, #75S20123P00004, and #HHSS283201700 075I/75S20321F42002.

NSIHT is owned and operated by Denver Health’s Rocky Mountain Poison and Drug Safety (RMPDS).

The views expressed on this website are those of RMPDS and not NIH, NIDA, nor SAMHSA.

 

 

FAQ

1. What is NSIHT?

The National Survey Investigating Hallucinogenic Trends (NSIHT) is an ongoing national surveillance study designed specifically to understand psychedelic use in the United States.

2. Why was NSIHT created?

NSIHT was created to address a specific goal. Traditional general-population surveys can measure psychedelic prevalence, but relatively low prevalence makes it difficult to study psychedelic specific substances, behaviors, contexts, benefits, risks, and emerging trends in depth. NSIHT complements existing national and international surveys by focusing on detailed, real-world psychedelic use while using statistical methods designed to support population-level inference. Its enriched sampling design allows NSIHT to study relatively uncommon substances and behaviors in greater depth than is typically possible in broad general-population surveys.

3. Who participates in NSIHT?

NSIHT collects surveys from adults in the US who have used at least one of seventeen psychedelic, hallucinogenic, or dissociative substances in the 12 months preceding the survey. All surveys are confidential and anonymous and data are protected by a NIH Certificate of Confidentiality. We collect these data through partnerships with commercial panel companies who help ensure we are measuring real people and their real experiences. We prioritize respondent trust and data quality because NSIHT asks about sensitive topics and experiences.

4. Why does NSIHT intentionally recruit more people who use psychedelics?

Use of many psychedelic substances and the corresponding experiences are uncommon in the general population. A conventional sample of thousands of randomly selected adults could contain very few people with experience using a particular substance. Enrichment gives NSIHT sufficient observations to investigate substance-specific behaviors and outcomes, and understand health outcomes associated with psychedelic use.

5. If NSIHT oversamples people who use psychedelics, how can its estimates be nationally representative?

The sample that is reporting psychedelic use alone is combined through statistical calibration and transport weighting techniques to a large population survey which allows estimates to be weighted to approximate the US adult population. This allows NSIHT to provide rich data on psychedelic use while bringing in the epidemiological population perspective. Our methods are outlined in the Data and Reports page for a full description of the weighting approach.

6. How often is NSIHT conducted?

NSIHT collects survey data during two launches per year, in the Summer and Winter. This allows for mid-year and annual trend detection and flexibility to measure the evolving landscape.

7. How does NSIHT make sure people understand and answer the questions reliably?

NSIHT survey content was designed after conducting focus groups and included lived-experience input, expert consultation, comprehension testing, and includes many validated instruments. NSIHT also conducted a test-retest reliability study of use of psychedelics in the last year, reasons for use, and recency of use. These findings can be found in our list of publications and methods documents on the Data and Reports page. NSIHT is committed to the continue validation and testing of the survey instrument.

8. What does “nationally representative” mean for NSIHT?

In NSIHT, nationally representative inference is produced analytically after data fusion and calibration. Estimates are meant to be nationally representative of all adults in the US.

9. Can NSIHT estimate psychedelic use in individual states?

Yes, NSIHT uses small area estimation to produce state-level population prevalence estimates for substance-specific psychedelic use in all 50 states and Washington D.C. These estimates can be accessed for free on the Data and Reports page. Our methods document outlines the two-stage validation approach taken to generate these estimates.

10. What are the limitations of NSIHT data?

NSIHT data are collected through anonymous, confidential surveys but are based on self-report and recall windows of the past 12 months. Given the nature of the sampling through commercial panel companies, there are some populations that NSIHT is not intended to provide inference to: Indigenous use practices, institutionalized adults, or overseas/deployed military personnel as examples. There may be some residual selection bias despite weighting and uncertainty for very uncommon substance-specific behaviors. Finally, the state estimates are based on small area estimation and therefore have some model dependence.

 

 

NSIHT Psychedelic Survey Research

National population survey monitoring the real-world use of psychedelics to understand prevalence of use, context of use, benefits, and harms.


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National Drug Use Surveys

National Drug Use Survey Capabilities

 

RMPDS is a leader in online population health surveys to capture drug use behaviors across the US and Canada.

National drug use surveys are a critical component of RMPDS’s mosaic surveillance methods, providing a robust way to measure prevalence of drug use and associated behaviors. Through rigorous survey design and online panel engagement, our tools capture prescription and over-the-counter medications, illicit drugs, cannabis, and other substances. 

These data are used by federal agencies including the FDA, Health Canada, and SAMHSA, state governments, drug sponsors, and advocacy and public health interest groups. 
 

Learn more about our National Drug Use Survey capabilities:

•    In 2025 Rocky Mountain will survey more than 131,400 people in the United States and Canada and more than 487,000 people since 2019
•    Survey design best practices: reliability testing, validation measures, and careless response mitigation
•    Ability to reach special populations: Veterans, students, racial groups, older adults, adolescents
•    Customize: deploy quickly with stakeholder-specific survey questions
•    Follow up and longitudinal methods: follow-up surveys and longitudinal follow up
 

Survey insights include:

  • Detailed demographics
  • National, Regional, and state level precision, census regions  
  • Validated health measures  
  • Drug specificity, down to formulations   
  • Designed to differentiate between illicit and Rx
  • Participant symptomology
  • Reason for use
  • Recency/frequency of use
  • Perceived benefits
  • Health history
  • Adverse events
 


 

 

NSIHT: National Survey Investigating Hallucinogenic Trends

National population survey monitoring the real-world use of psychedelics to understand prevalence of use, context of use, benefits, and harms.


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COUNTS: Cannabis Outcomes & Use National Target Survey

Investigation designed to provide comprehensive understanding of cannabis use and trends of use within specific cannabis formulations.


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GOLDS: General Online Longitudinal Drug Survey

Longitudinal study established to further define best practices in survey design, deployment, bias detection in survey behaviors and how drug use trajectories change as individuals lived experiences change.


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NMURx: Survey of Non-medical Use of Prescription Drugs

This survey describes medication use without a doctor’s prescription and use outside what a doctor has prescribed. Prescription drugs include: opioids, sedatives, stimulants, and tranquilizers. 


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OTC: Survey of Over the Counter Medications

A fit-for-purpose survey that provides insight into the behaviors, preferences, safety, and effectiveness of over-the-counter medications and other consumer products among adults and adolescents in the US.


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Custom Built: Work with our team to design your study

Let’s discuss your research needs, our team is prepared to provide study design surveys, IRB submission, survey deployment and data collection and management services.


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Learn More About Our Psychedelic Studies

National Survey Investigating Hallucinogenic Trends (NSIHT)

Summary

NSIHT focuses on individuals actively using psychedelics to inform overall safety, utility, and effectiveness using real-world evidence. This cross-sectional surveillance pilot study intends, over time, to be the most comprehensive study of psychedelic use in the United States. It was informed through focus groups and underwent external expert reviews. 

Launched in April of 2024, the survey has over 4,300 respondents to date, capturing the following data: 

Development of pilot funded through US Substance Abuse and Mental Health Administration (SAMHSA) contract #A23-0105-00_9810

 

To learn more or for collaboration opportunities & additional survey capabilities, please contact us

Sentinel Poison Center

Summary

This is a surveillance system of psychedelic drug exposures reported to US Poison Centers. The primary purpose of this study is to quantify and monitor the number of adverse events and medical outcomes associated with psychedelic drug use reported to US poison centers. 

This augmented approach to poison center data collection will capture contextual and clinical variables currently not well captured by poison centers.

The Sentinel poison center program is currently collecting data on psychedelic safety in 4 states (Colorado, Hawaii, Nevada, and Montana).

RMPDS Sentinel Poison Center Program

 

To learn more or for collaboration opportunities, please contact us

Longitudinal Psychedelic Treatment Study - Healing Centers

As new psychedelic drugs emerge, understanding their real-world safety and effectiveness is crucial. Treatments like psilocybin and ketamine are being explored for mental health conditions, with FDA-approved esketamine already available for treatment-resistant depression. While promising, these treatments come with potential risks and benefits that need thorough investigation.

The Healing Centers study is an observational, longitudinal project that will collect patient data over approximately one year. It aims to gather:

  • Demographic and medical history to describe participants.
  • Pre- and post-treatment data to analyze changes in mental health symptoms and overall wellbeing.
  • Quantitative and qualitative experiences to identify any negative outcomes or adverse events.

Key measures will include patient perceptions of health, wellbeing, social support, psychological insight, and serious adverse events like hospitalization.

Data collection is active in 15 clinics in 7 states.

Current Site Enrollment Locations:

Healing Centers current site enrollment map

For more information about our Longitudinal Psychedelic Treatment Study - Healing Centers program or to enroll, please contact us


Psychedelic Studies

Fit-for-Purpose Data Collection


 

Rocky Mountain leads the development of fit-for-purpose surveillance tools to monitor the safety and effectiveness of psychedelic therapies. Well-designed tools are important to maximizing the safe use of these therapies. The application of these psychedelic safety and effectiveness data include public health monitoring, premarket safety evaluations, and REMS evaluations.

 

We work alongside many brands to provide data & insights that matter.

Monitoring for Brands that Matter

 

 

National Survey Investigating Hallucinogenic Trends (NSIHT)

National population survey monitoring the real-world use of psychedelics to understand prevalence of use, context of use, benefits, and harms.


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Sentinel Poison Center

Surveillance of psychedelic safety at US poison centers through augmented data collection methods.


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Longitudinal Psychedelic Treatment Study

An observational, longitudinal study to understand the outcomes, impact, and participant journeys of psychedelic and dissociative treatments for mental health.


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Publications

Our team is disseminating the results of our work through manuscripts, abstracts, and presentations.


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Rocky Mountain Data Collection Leadership

We are led by a multi-disciplinary team of clinical, scientific, and methodological experts.


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Ready To Explore?

We are eager to discuss with you how we can help you meet your psychedelic data collection needs.


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Public Access Data

Rocky Mountain leads the development of fit-for-purpose surveillance tools to monitor the safety and effectiveness of psychedelic therapies. Well-designed tools are important to maximizing the safe use of these therapies. The application of these psychedelic safety and effectiveness data include public health monitoring, premarket safety evaluations, and REMS evaluations

Public Data

Drug Use in the United States


This dashboard highlights data from the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS®) System which has been monitoring drug use since 2006. We pride ourselves on combining data across sources to provide a more accurate and complete picture of drug use in the United States.   

Explore our dashboard below! Each tab focuses on a different facet of drug use, misuse, abuse, and diversion. On any page, use the tabs at the top to navigate to a topic of interest and the selection tool on the right to choose the type of drug you are interested in learning more about. Hover over data to see more detail.


 

Learn More About Our Postmarketing Surveillance

Mosaic Surveillance & Triangulation

  • Web population survey
  • Therapeutic use of psychedelics
  • Non-therapeutic substance use
  • Acute health effects
  • Mortality data
  • Drug transaction data
  • Street price information
  • Web discussion

 

For more information about mosaic surveillance and triangulation, please contact us

Observational Studies

  • Study design
  • Real-world data
  • Data collection and management
  • Epidemiological studies
  • Longitudinal studies
  • Biostatistical analysis
  • Custom-built research tools

For more information about observational studies, please contact us

National Poison Data System Studies

  • Outcomes with intentional and unintentional exposures
  • Adverse event information
  • Data on special populations -- suicide, children, older adults

 

For more information about National Poison Data System studies, please contact us

Literature Surveillance

  • Customized search strategies
  • Continuous monitoring
  • Synthesis of insights

 

For more information about literature surveillance, please contact us

Benchmarking and Safety

  • Signal detection
  • Human abuse potential study design
  • Retrospective and prospective data
  • Diversion risk
  • History, trends, and patterns of use

 

For more information about benchmarking and safety, please contact us


Patient Health & Medical Toxicology Services Learn More

Telemedicine

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Clinical Care

Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32. The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

Medical Toxicology Training

Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32. The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

Healthcare System Navigation

Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32. The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

Publications/Posters

Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32. The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

Patient Stories

Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32. The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.


Consulting

Adverse Event Signal Detection

  • Data analysis and interpretation
  • Risk assessment
  • Medical information and pharmacovigilance
  • Acute health effects

 

For more information about adverse event signal detection, please contact us

Data Analytics

  • Data integration and visualization
  • Advanced analytics
  • Real-time monitoring

 

For more information about data analytics, please contact us

Study Design & Protocol Development

  • Methodology development
  • Risk assessment
  • Reporting and dissemination
  • Regulatory compliance

 

For more information about study design and protocol development, please contact us

Public Health Responses

  • Safety signal management
  • Public health communication
  • Risk management plans
  • Education and training
  • US State data on drug use

 

For more information about public health responses, please contact us

Toxicology

  • Board-certified medical toxicologists
  • Adverse event management
  • Product development
  • Education and training

 

For more information about toxicology, please contact us

Database Development

  • Adverse event reporting
  • Signal detection and assessment
  • Product quality complaints

 

For more information about database administration and development, please contact us


Medical Information & Pharmacovigilance Learn More

Streamlined Adverse Event & Product Complaint Intake

  • Predominate expert PharmD Staff
  • HCP agent live answer (we never use non-HCP to triage calls)
  • Robust initial data collection and documentation
  • Premium reporting and data utiliztaion
  • Expert recognition of hidden events with mature probing for more complete reports

For more information about streamlined adverse event and product complaint intake, please contact us

International Telephony

  • Multi-channel configuration
  • Robust IVR configurability
  • Reportable non-recorded lines for privacy regulation compliance
  • Disaster recovery/redundant systems
  • Call recording for quality review
  • Speech analytics and AI quality monitoring

For more information about international telephony, please contact us

Pharmacovigilance

  • On-time regulatory submissions and reporting
  • Aggregate, periodic and expedited reporting (PSUR and PADAR, etc.)
  • Data migration
  • SDEA
  • Agency audit support
  • Literature surveillance
  • Risk management services
  • MedDRA and WHO drug coding

For more information about pharmacovigilance, please contact us

Turnkey Medical Information Database

  • Internal clinical system implementation administrators
  • Streamlined onboarding and client-specific modifications
  • Customized data collection configurations 
  • Fully validated system incorporating regulatory and privacy requirements

For more information about turnkey medical information database, please contact us

Medical Information Insights

  • Industry standards through best practices
  • Real-time, interactive, configurable dashboards
  • Customized data points
  • PharmD analysis 

For more information about medical information insights, please contact us

System integrations

  • Bi-directional CRM integrations
  • Content integrations with industry standard document repositories
  • PV and quality system integration (XML output)
  • CRM Contact integrations
  • Portal webform intake

For more information about system integrations, please contact us


Scientific Communication Learn More

Publication Strategies

  • Literature reviews and meta-analyses
  • Manuscript writing
  • Conference abstract and presentation generation
  • Collaborative research and authorship
  • Regulatory submissions and white papers

 

For more information about publication strategies, please contact us

Medical Writing

  • Clinical trial documentation
  • Adverse event reports
  • Educational and training materials
  • Medical and safety communications

 

For more information about medical writing, please contact us